OrganoSpheres Consortium
Where Israeli industry and academia join forces to pave the way for more effective and individualized medicine.
Our Vision
Create a shared technological and data infrastructure, based on the development and optimization of 3D cellular systems methods, characterization tools and process standardization. These cultures from healthy or pathological sources hold the promise of transforming basic science and therefore translating it into clinical research, drug discovery and personalized medicine.
Unmet needs
Limited ability to mimic a tumor microenvironment.
Translating cultures findings into clinical applications.
Implementing 3D cultures as a robust solution for large patient populations.
Improve 3D cultures reproducibility, and establish protocols for use in clinical settings
Technological gaps
Systems propagation from low amounts of cells.
The use of non-trivial sources like blood samples and urine.
Increase success rate of 3D cellular systems.
Long-term tissue preservation.
Add tumor microenvironment elements such as blood vessels and immune cells.
AI-based applications to predict success or to assess cell quantity without dissociation.
Background
Organoids, three-dimensional (3D) multicellular structures, have emerged as a groundbreaking tool in the realm of cancer research, offering a more physiologically relevant model compared to traditional 2D cell cultures. One of the most promising aspects of organoids is their ability to recapitulate the cellular heterogeneity and architecture of the original tumor.
Tech
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